We study how functional constraints bound and shape evolution through an analysis of mammalian voltage-gated sodium channels.The primary function of sodium channels is to allow the propagation of action potentials.Since Hodgkin and Huxley, mathematical models have suggested that sodium channel properties need to be tightly constrained for an action
Sponges, despite their simple body plan, discriminate between self and nonself with remarkable specificity.Sponge grafting experiments simulate the effects of natural self or nonself contact under laboratory conditions.Here we take a transcriptomic approach to investigate the temporal response to self and nonself grafts in the marine demosponge Amp
Hydraulic systems are used in all kinds of industries.Mills, manufacturing, robotics, and Ports require the use of Hydraulic Equipment.Many industries prefer to use hydraulic systems due to their numerous advantages Wooden puzzle over electrical and mechanical systems.Hence, the growth in demand for hydraulic systems has been increasing over time.D
The fundamental equations of the two dimensional generalized Glasses thermoelasticity (L-S model) with one relaxation time parameter in orthotropic elastic slab has been considered under effect of rotation.The normal mode analysis is used to the basic equations of motion and heat conduction equation.Finally, the resulting equations are written in t
BACKGROUND: Severe Pants burn injury results in the loss of intestinal barrier function, however, the underlying mechanism remains unclear.Myosin light chain (MLC) phosphorylation mediated by MLC kinase (MLCK) is critical to the pathophysiological regulation of intestinal barrier function.We hypothesized that the MLCK-dependent MLC phosphorylation